She said that this does not work for patients who have HIV, but not a blood cancer as well. “He had lived with HIV the longest of the four patients for over 31 years and he received the least immunosuppressive regimen prior to transplant compared to the three previous patients.” “His experience was unique from the other cases given that at the age of 63 he was the oldest patient to receive a stem cell transplant and then go on to receive dual remission,” Dickter added. “And people who carry this mutation are resistant to most strains of HIV infection,” she said. The entire team at City of Hope is honored to make a difference every day in the lives of people with cancer, diabetes and other life-threatening diseases.”ĭickter explained how this happened - the result of a stem-cell transplant from a donor carrying the homozygous CCR5 Delta 32 mutation, she said. “It is humbling to know that our pioneering science in bone marrow and stem cell transplants, along with our pursuit of the best precision medicine in cancer, has helped transform this patient’s life. “We are proud to have played a part in helping the City of Hope patient reach remission for both HIV and leukemia,” Stone said. (Courtesy photo)Ĭity of Hope CEO/President Robert Stone, in a statement, was elated. Dickter, M.D., is associate clinical professor in the Division of Infectious Diseases at City of Hope Medical Center in Duarte.
To be able to say that to someone is really amazing.” Jana K.
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“I mean, as an infectious disease doctor, I always wanted to tell patients that they might be free of their HIV. “It is a big deal,” she said, Wednesday afternoon, via telephone.
in 1981.ĭickter, associate clinical professor in the Division of Infectious Diseases at City of Hope, presented the data virtually Wednesday at the AIDS 2022 press conference. HIV is the virus that causes AIDS, which was first diagnosed in the U.S. The method makes the transplant more tolerable for older patients and reduces the potential for complications from the procedure. Prior to the transplant, the patient went through a chemotherapy-based, reduced-intensity transplant regimen that was developed by City of Hope and other transplant programs for treatment of older patients with blood cancers. His case presents opportunities for older patients with HIV and a blood cancer to achieve remission for both if a donor with this rare genetic mutation can be identified. He is the fourth person in the world to go into long-term remission for at least a year without the use of ART after such a transplant.Īmong the four, he had HIV the longest. The patient, who did not want to be identified, received the transplant in early 2019 and has been in remission for the past 17 months after he stopped taking antiretroviral therapy (ART) for HIV in March 2021. Dickter of the City of Hope, the patient’s numbers actually showed that, by definition, he had already developed AIDS upon his original HIV diagnosis in 1988. In effect, he appears to have beaten the virus.Īccording to Dr.